SYNTHESIS, ANTIMICROBIAL ACTIVITY, UREASE INHIBITION AND MOLECULAR DOCKING STUDIES OF NEW PROLINE LINKED THIOUREA DERIVATIVES

Ahmad RAHEEL; Imtiaz-Ud-DIN; Syed Hassan IFTIKHAR; Muhammad Babar TAJ; Rabia AYUB; Anham ZAFAR; Sumaira ABBAS; Mundher AL-SHAKBAN

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SYNTHESIS, ANTIMICROBIAL ACTIVITY, UREASE INHIBITION AND MOLECULAR DOCKING STUDIES OF NEW PROLINE LINKED THIOUREA DERIVATIVES

机译：新型脯氨酸连接硫脲衍生物的合成，抗菌活性，脲酶抑制和分子对接研究

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A series of new thiourea based carboxylic acids (I_a-I_e) were synthesized and characterized by elemental analysis, FTIR and NMR (~1H and ~(13)C) spectroscopy. They were preliminary bioassayed for their antibacterial, anifungal and urease inhibition activities. Molecular docking simulations were carried out to determine the probable binding mode of the synthesized compounds. The bioassay results showed that some of titled compounds exhibited encouraging results.

机译：通过元素分析，FTIR和NMR（〜1H和〜（13）C）光谱合成并表征了一系列新的硫脲基羧酸（I_A-I_E）并表征。它们是初步生物测量的抗菌，腹泻和释放释放活性。进行分子对接模拟以确定合成化合物的可能结合模式。生物测定结果表明，一些标题化合物表现出令人鼓舞的结果。

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来源
《Revue roumaine de chimie》 |2020年第9期|783-788767|共7页
作者
Ahmad RAHEEL; Imtiaz-Ud-DIN; Syed Hassan IFTIKHAR; Muhammad Babar TAJ; Rabia AYUB; Anham ZAFAR; Sumaira ABBAS; Mundher AL-SHAKBAN;
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作者单位

Department of Chemistry Quaid-i-Azam University Islamabad 45320 Pakistan;

Department of Chemistry Quaid-i-Azam University Islamabad 45320 Pakistan;

Department of Chemistry University of Engineering and Technology Lahore 54890 Pakistan;

Department of Chemistry Quaid-i-Azam University Islamabad 45320 Pakistan Department of Chemistry Baghdad-ul-Jadid Campus Islamia University of Bahawalpur Bahawalpur 63100 Pakistan Department of chemistry University of Sahiwal Sahiwal 57000 Pakistan;

Department of Organic Chemistry Arrhenius Laboratory Stockholm University SE-10691 Stockholm Sweden;

Department of Chemistry Quaid-i-Azam University Islamabad 45320 Pakistan;

Department of Chemistry Quaid-i-Azam University Islamabad 45320 Pakistan;

Department of Chemistry University of Manchester M13 9PL England;

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原文格式 PDF
正文语种 eng
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关键词
antimicrobial; enzyme inhibition; molecular docking;

机译：抗菌剂;酶抑制;分子对接;

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机译：新型脯氨酸连接硫脲衍生物的合成，抗菌活性，脲酶抑制和分子对接研究

SYNTHESIS, ANTIMICROBIAL ACTIVITY, UREASE INHIBITION AND MOLECULAR DOCKING STUDIES OF NEW PROLINE LINKED THIOUREA DERIVATIVES

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