Analyzing Quantitative Trait Loci for the Arabidopsis thaliana using Markov Chain Monte Carlo Model Composition with restricted and unrestricted model spaces

摘要

Quantitative Trait Loci (QTL) mapping is a growing field in statistical genetics. However, dealing with this type of data from a statistical perspective is often perilous. In this paper we extend and apply a Markov Chain Monte Carlo Model Composition (MC~3) technique to a data set of the Arabidopsis thaliana plant for locating the QTL mapping associated with cotyledon opening. The posterior model probabilities as well as the marginal posterior probabilities of each locus belonging to the model are presented. Furthermore, we show how the MC~3 method can be used to deal with the situation where the sample size is less than the number of parameters in a model using a restricted model space approach.