Synthesis and Biological Testing of Certain 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives as Potential Antimicrobial Agents

摘要

A series of hydrazones, thiosemicarbazides and 2,5-disubstituted-1,3,4-oxadiazoles bearing 3,4,5-trimethoxyphenyl moiety was synthesized. Furthermore, the reaction of the prepared 1-(3,4,5-trimethoxybenzoyl)thiosemicarbazide and 3-(3,4,5-trimethoxy-phenyl)-4H-5-mercapto-1,2,4-triazole with α-haloketone was investigated. Some of the newly prepared compounds showed remarkable antifungal and moderate antibacterial activities.