Models of Ca~(2+) Release Channel Adaptation

摘要

Channel adaptation (1) involves complex behavior of the sarcoplasmic reticulum (SR) Ca~(2+) release channel (ryanodine receptor, RyR). The adaptive behavior is different from conventional ion channel behavior in that adapting channels transiently activate (open) in response to repeated increments of agonist (Ca~(2+)). No published kinetic model known to us could adequately account for this adaptation. We propose a model that readily accounts for the complexities associated with adaptation.