Diverse antibody production by B cells, which is critical for protection against a variety of infections, often requires the help of T cells. Marginal zone (MZ) B cells in the spleen, which are situated at the interface of the circulation and the immune system, are unusual in that they are able to provide a rapid, first line of antibody defense that is independent of T cells. Puga ef al. now show that despite being independent of T cells, MZ B cells in humans do get help from another immune cell: neutrophils.
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