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首页> 外文期刊>Science >Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
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Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

机译：循环乳腺肿瘤细胞上皮和间充质组成的动态变化

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摘要

Epithelial-mesenchymal transition (EMT) of adherent epithelial cells to a migratory mesenchymal state has been implicated in tumor metastasis in preclinical models. To investigate its role in human cancer, we characterized EMT in circulating tumor cells (CTCs) from breast cancer patients. Rare primary tumor cells simultaneously expressed mesenchymal and epithelial markers, but mesenchymal cells were highly enriched in CTCs. Serial CTC monitoring in 11 patients suggested an association of mesenchymal CTCs with disease progression. In an index patient, reversible shifts between these cell fates accompanied each cycle of response to therapy and disease progression. Mesenchymal CTCs occurred as both single cells and multicellular clusters, expressing known EMT regulators, including transforming growth factor (TGF)-β pathway components and the FOXC1 transcription factor. These data support a role for EMT in the blood-borne dissemination of human breast cancer.
机译：在临床前模型中，粘附上皮细胞向迁移性间充质状态的上皮-间质转化（EMT）与肿瘤转移有关。为了研究其在人类癌症中的作用，我们对来自乳腺癌患者的循环肿瘤细胞（CTC）中的EMT进行了表征。罕见的原发性肿瘤细胞同时表达间充质和上皮标记，但间充质细胞高度富集CTC。对11例患者进行的连续CTC监测表明，间充质CTC与疾病进展相关。在索引患者中，这些细胞命运之间的可逆转变伴随着对治疗和疾病进展的每个反应周期。间充质CTCs以单细胞和多细胞簇的形式出现，表达已知的EMT调节剂，包括转化生长因子（TGF）-β途径成分和FOXC1转录因子。这些数据支持EMT在人类乳腺癌的血源性传播中的作用。

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  • 来源
    《Science》 |2013年第6119期|580-584|共5页
  • 作者

    Min Yu; Aditya Bardia; Ben S. Wittner; Shannon L. Stott; Malgorzata E. Smas; David T. Ting; Steven J. Isakoff; Jordan C. Ciciliano; Marissa N. Wells; Ajay M. Shah; Kyle F. Concannon; Maria C. Donaldson; Lecia V. Sequist; Elena Brachtel; Dennis Sgroi; Jose Baselga; Sridhar Ramaswamy; Mehmet Toner; Daniel A. Haber; Shyamala Maheswaran;

  • 作者单位

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA,Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA,Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA,Center for Bioengineering in Medicine, Harvard Medical School, Charlestown, MA 02129, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA,Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA;

    Center for Bioengineering in Medicine, Harvard Medical School, Charlestown, MA 02129, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA,Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA,Department of Pathology, Harvard Medical School, Charlestown, MA 02129, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA,Department of Pathology, Harvard Medical School, Charlestown, MA 02129, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA,Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA,Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA;

    Center for Bioengineering in Medicine, Harvard Medical School, Charlestown, MA 02129, USA,Department of Surgery, Harvard Medical School, Charlestown, MA 02129, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA,Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA,Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA;

    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA,Department of Surgery, Harvard Medical School, Charlestown, MA 02129, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-18 02:52:47

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