The correlation between PM_(2.5) exposure and hypertensive disorders in pregnancy: A Meta-analysis

摘要

Objective: To find the correlation between exposure to PM_(2.5) (fine particulate matter) and hypertensive disorders in pregnancy (HDP), and provide medical evidence for decreasing the incidence of hypertensive disorders in pregnancy. Method: A combination of computer and manual retrieval was used to search for keywords in PubMed (385 records), Cochrane Library (20 records), Web of Science (419 records) and Embase (325 records). Finally, ten epidemiological articles were considered in this meta-analysis. Stata 13.0 was used to examine the heterogeneity among the studies and to calculate the combined effect value (OR, odds ratio) by selecting the corresponding models. Sensitivity analysis and publication bias test were also performed. Results: Meta-analysis indicated that there was an association between PM_(2.5) exposure (per 10μg/m~3 increase) and hypertensive disorders in pregnancy (OR = 1.52, 95% CI: 1.24-1.87). Exposure to PM_(2.5) (per 10μg/m~3 increase) enhanced the risk of pre-eclampsia (OR = 1.31, 95% CI: 1.07-1.61), but there was no evidence relating exposure to PM_(2.5) to gestational hypertension (OR = 1.35, 95% CI: 0.98-1.87). Conclusion: There is a significant link between exposure to PM_(2.5) and hypertensive disorders in pregnancy. The first and the third trimester were more susceptible to PM_(2 5) exposure. It is recommended to further strengthen protective measures against PM_(2.5) during pregnancy.