首页> 外文期刊>Acta Ciencia Indica. Chemistry >NEW SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF ITOPRIDE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS
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NEW SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF ITOPRIDE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS

机译:分光光度法测定药物制剂中盐酸盐酸碘的新方法。

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摘要

Two simple and sensitive spectrophotometric methods, A and B are developed for the determination of itopride hydrochloride in bulk and pharmaceutical dosage forms. Method A is based on the reaction of itopride hydrochloride with folin-ciocalteu (FC) reagent under alkaline conditions to form a colored chromogen ( λ_(max) : 690 nm). Method B is based on the formation of an ion-pair complex between itopride hydrochloride and Bromothymol blue (BTB) (λ_(max) : 420 nm). When Pharmaceutical formulations (Tablets) containing itopride were analysed, the result obtained by the proposed method are in good agreement with the labeled amount. Recovery in both the methods is 98-λ_(max).
机译:开发了两种简单而灵敏的分光光度法A和B,用于测定散装和药物剂型中的盐酸伊托必利。方法A是基于盐酸伊托必利与碱性条件下的folin-ciocalteu(FC)试剂反应形成彩色发色团(λ_(max):690 nm)。方法B基于在盐酸伊托必利和溴百里酚蓝(BTB)(λ_(max):420 nm)之间形成离子对络合物。当分析含有伊托必利的药物制剂(片剂)时,通过建议的方法获得的结果与标记的量非常吻合。两种方法的回收率均为98-λ_(max)。

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