NEW SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF ITOPRIDE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS

摘要

Two simple and sensitive spectrophotometric methods, A and B are developed for the determination of itopride hydrochloride in bulk and pharmaceutical dosage forms. Method A is based on the reaction of itopride hydrochloride with folin-ciocalteu (FC) reagent under alkaline conditions to form a colored chromogen ( λ_(max) : 690 nm). Method B is based on the formation of an ion-pair complex between itopride hydrochloride and Bromothymol blue (BTB) (λ_(max) : 420 nm). When Pharmaceutical formulations (Tablets) containing itopride were analysed, the result obtained by the proposed method are in good agreement with the labeled amount. Recovery in both the methods is 98-λ_(max).