Comparative study on the induction of apoptosis by anties- trogens in the estrogen receptor negative ovarian cancer cell line a2780

摘要

The nonsteroidal drug tamoxifen (TAM) is a triphenylethylene-derived agent with partial antiestrogenic activity used as the drug of choice in endocrine breast cancer therapy. Two main effects have been described to explain the anti- proliferative activity of TAM: a cytostatic effect by which estrogen receptor (ER) positive cells are blocked by low drug concentrations (1 μM-1μM) in G1 phase and a cytotoxic effect characterized by cell death with the feature of apoptosis of ER positive and ER negative cells triggered by higher TAM concentrations (>5μM).