In situ synthesis of polyamidoamine/β-cyclodextrin/silver nanocomposites on polyester fabric tailoring drug delivery and antimicrobial properties

摘要

Here, the polyester fabric was modified using polyamidoamine/beta-cyclodextrin (beta-CD)/silver nanocomposites to make a fabric with antibacterial and drug delivery properties. The aminolysis of polyester fabric with polyamidoamine led to the possible stable linkages with (beta-CD)/Ag composites. The drug absorption and release behavior of the fabrics investigated in the water and phosphate buffer solutions confirming the maximum drug absorption of 16.9% after 24 h in which 45% of the loaded drug was slowly released in the buffer solution after 3 h. The synthesized nanocomposites on the fabric were detected by FESEM images and EDX mapping showed various percentages and distribution of the used elements. Also, FTIR analysis displayed some changes in the chemical structure of the functional groups. The XRD pattern of beta-CD/Ag nanocomposite suggested a peak at 2 theta = 44.6 degrees with the calculated crystal size of 9.5 nm. The tensile strength unremarkably decreased according to the mechanical testing. Further, the treated fabrics indicated 100, 100 and 99% microbial reduction against E. coli, S. aureus and C. albican. Moreover, the cytotoxicity of the fabric against fibroblast cell was studied through MTT test. Based on the obtained results, it can suggest that the new modified polyester fabric can be used in drug delivery system.