Synthesis, Characterization, and Drug Encapsulation of Hyperbranched Polyamidoamine Modified by β-Cyclodextrin

摘要

h-PAMAM-COOMe and its β-CD derivatives (h-PAMAM-CD) were synthesized step by step via the Michael addition and ester-aminolysis reaction from hyperbranched polyamidoamine (h-PAMAM). The structures of the as-prepared polymers were confirmed by Ubbelohde viscometer, FTIR, and 1H NMR. A series of inclusion complexation formed by β-naphtol in increasing h-PAMAM-β-CD with different concerntration were investigated by UV-vis spectrometer. The result showed that the novel hyperbranched polymer might have potential applications as delivery materials in chemotherapy.