STUDY OF VOLATILE COMPOUNDS FROM THE RADIOSTERILIZATION OF SOLID CEPHALOSPORINS

摘要

The use of γ-rays is a promising method to sterilize thermosensitive drugs. Although radiosterilization does not modify drugs activity, this mode of sterilization produces new radiolytic products. This study is devoted to the analysis of volatile compounds which may induce a modification of odour. The volatile compounds produced by radiolysis of cefotaxime, cefuroxime and ceftazidime, three cephalosporins, were analyzed by gas chromatography with headspace sampling. They were detected and identified by mass and infrared spectrometry. An explanation of their origin is proposed.