Familial Mediterranean fever (FMF) is classically an autosomal recessive periodic inflammatory disease occurring in Mediterranean and Middle Eastern populations. It is caused by mutations affecting both alleles of MEFV, a gene that encodes pyrin (marenostrin), an uncharacterized neutrophil pro- tein. Occasional reports of autosomal dominant FMF have often been discounted, on the basis that Asymptomatic FMF carriers are common in certain Populations, and give rise to pseudo-dominant Inheritance.
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