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Structure-based protein-protein interaction networks and drug design

机译:基于结构的蛋白质-蛋白质相互作用网络和药物设计

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摘要

Proteins carry out their functions by interacting with other proteins and small molecules, forming a complex interaction network. In this review, we briefly introduce classical graph theory based protein-protein interaction networks. We also describe the commonly used experimental methods to construct these networks, and the insights that can be gained from these networks. We then discuss the recent transition from graph theory based networks to structure based protein-protein interaction networks and the advantages of the latter over the former, using two networks as examples. We further discuss the usefulness of structure based protein-protein interaction networks for drug discovery, with a special emphasis on drug repositioning.
机译:蛋白质通过与其他蛋白质和小分子相互作用而形成复杂的相互作用网络,从而发挥其功能。在这篇综述中,我们简要介绍了基于经典图论的蛋白质-蛋白质相互作用网络。我们还描述了构建这些网络的常用实验方法,以及可以从这些网络中获得的见解。然后,我们以两个网络为例,讨论从基于图论的网络到基于结构的蛋白质-蛋白质相互作用网络的最新转变,以及后者相对于前者的优势。我们进一步讨论基于结构的蛋白质-蛋白质相互作用网络对药物发现的实用性,并特别强调药物重新定位。

著录项

  • 来源
    《Quantitative biology》 |2013年第3期|183-191|共9页
  • 作者

    Hammad Naveed; Jingdong J. Han;

  • 作者单位

    Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;

    Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    protein-protein interaction; network; structure-based; drug design; drug reposition;

    机译:蛋白质相互作用网络;基于结构药物设计;药物重新定位;

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