Nicotinic acetylcholine receptors in the ventral tegmental area mediate the dopamine activating and reinforcing properties of ethanol cues

Elin Löf; Peter Olausson; Andrea deBejczy; Rosita Stomberg; J. Michael McIntosh; Jane R. Taylor; Bo Söderpalm

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Nicotinic acetylcholine receptors in the ventral tegmental area mediate the dopamine activating and reinforcing properties of ethanol cues

机译：腹侧被盖区的烟碱乙酰胆碱受体介导乙醇线索的多巴胺激活和增强特性

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Cues associated with alcohol can elicit craving, support drug-seeking and precipitate relapse.

机译：与酒精有关的提示会引起渴望，支持寻求药物和促使复发。

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来源
《Psychopharmacology》 |2007年第3期|333-343|共11页
作者
Elin Löf; Peter Olausson; Andrea deBejczy; Rosita Stomberg; J. Michael McIntosh; Jane R. Taylor; Bo Söderpalm;
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作者单位

Inst. Neuroscience and Physiology Sect. Psychiatry and Neurochemistry Sahlgrenska Academy Göteborg University and Beroendekliniken Sahlgrenska University Hospital Gothenburg Sweden;

Department of Psychiatry Div. of Molecular Psychiatry School of Medicine Yale University New Haven CT USA;

Inst. Neuroscience and Physiology Sect. Psychiatry and Neurochemistry Sahlgrenska Academy Göteborg University and Beroendekliniken Sahlgrenska University Hospital Gothenburg Sweden;

Inst. Neuroscience and Physiology Sect. Psychiatry and Neurochemistry Sahlgrenska Academy Göteborg University and Beroendekliniken Sahlgrenska University Hospital Gothenburg Sweden;

Department of Psychiatry University of Utah Salt Lake City UT USA;

Department of Psychiatry Div. of Molecular Psychiatry School of Medicine Yale University New Haven CT USA;

Inst. Neuroscience and Physiology Sect. Psychiatry and Neurochemistry Sahlgrenska Academy Göteborg University and Beroendekliniken Sahlgrenska University Hospital Gothenburg Sweden;

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正文语种 eng
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关键词
Acetylcholine; Ventral tegmental area; Addiction; Alcohol; Conditioned reinforcement; Dopamine; Nicotinic receptor; Nucleus accumbens;

机译：乙酰胆碱;腹侧被盖区;成瘾;酒精;条件增强;多巴胺;烟碱受体;伏隔核;

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1. Nicotinic acetylcholine receptors in the ventral tegmental area mediate the dopamine activating and reinforcing properties of ethanol cues. [J] . Lof E, Olausson P, deBejczy A, Psychopharmacology . 2007,第3期

机译：腹侧被盖区的烟碱乙酰胆碱受体介导乙醇提示的多巴胺活化和增强特性。
2. Nicotinic acetylcholine receptors in the anterior, but not posterior, ventral tegmental area mediate ethanol-induced elevation of accumbal dopamine levels. [J] . Ericson M, Lof E, Stomberg R, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2008,第1期

机译：前腹侧被盖区的烟碱乙酰胆碱受体介导乙醇诱导的累积多巴胺水平升高。
3. Ethanol elevates accumbal dopamine levels via indirect activation of ventral tegmental nicotinic acetylcholine receptors. [J] . Ericson M, Molander A, Lof E, European Journal of Pharmacology: An International Journal . 2003,第1a3期

机译：乙醇可通过间接激活腹侧被膜烟碱型乙酰胆碱受体来提高伏安多巴胺水平。
4. Regulation of Dopamine Release by Striatal Acetylcholine and Nicotine Is via Distinct Nicotinic Acetylcholine Receptors in Dorsal vs. Ventral Striatum [C] . Richard Exley, Michael A. Clements, Stephanie J. Cragg Triennial Meeting of the International Basal Ganglia Society . 2009

机译：通过纹状体乙酰胆碱和尼古丁对多巴胺释放的调节是通过不同的烟碱乙酰胆碱受体在背侧与腹侧纹状体中
5. The Roles of Nicotinic Acetylcholine Receptors in the Ventral Tegmental Area: Implications in Nicotine and Ethanol Addiction and Drug Intervention [D] . Taylor, Devin 2015

机译：烟碱乙酰胆碱受体在腹侧被盖区的作用：对尼古丁和乙醇成瘾和药物干预的影响。
6. Nicotinic Acetylcholine Receptors in the Mesolimbic Pathway: Primary Role of Ventral Tegmental Area α6β2* Receptors in Mediating Systemic Nicotine Effects on Dopamine Release Locomotion and Reinforcement [O] . Cecilia Gotti, Stefania Guiducci, Vincenzo Tedesco, 2010

机译：中脑边缘途径中的烟碱型乙酰胆碱受体：腹侧被盖区α6β2*受体在介导全身性尼古丁对多巴胺释放运动和增强的作用中的主要作用
7. Nicotinic Acetylcholine Receptors in the Mesolimbic Pathway: Primary Role of Ventral Tegmental Area 6 2* Receptors in Mediating Systemic Nicotine Effects on Dopamine Release, Locomotion, and Reinforcement [O] . C. Gotti, S. Guiducci, V. Tedesco, 2010

机译：培养基途径中的烟碱乙酰胆碱受体：腹侧腹部面积6 2 *受体对多巴胺释放，运动和加固介导的系统性尼古丁作用的主要作用
8. Use of Monoclonal Antibodies to Study the Structural Basis of the Function of Nicotinic Acetylcholine Receptors on Electric Organ and Muscle and to Determine the Structure of Nicotinic Acetylcholine Receptors on Neurons. [R] . Lindstrom, J. M. 1989

机译：使用单克隆抗体研究烟碱型乙酰胆碱受体在电活动器官和肌肉上的功能结构基础，并确定神经元上烟碱型乙酰胆碱受体的结构。

Nicotinic acetylcholine receptors in the ventral tegmental area mediate the dopamine activating and reinforcing properties of ethanol cues

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