LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT_2A receptor

摘要

Rationale Compounds that activate the 5-HT_2A receptor, such as lysergic acid diethylamide (LSD), act as hallucinogens in humans. One notable exception is the LSD congener lisuride, which does not have hallucinogenic effects in humans even though it is a potent 5-HT_2A agonist. LSD and other hallucinogens have been shown to disrupt prepulse inhibition (PPI), an operational measure of sensorimotor gating, by activating 5-HT_2A receptors in rats.