Social instigation and aggression in postpartum female rats: role of 5-Ht_1A and 5-Ht_1B receptors in the dorsal raphé nucleus and prefrontal cortex

摘要

Rationale 5-HT_1A and 5-HT_1B receptor agonists effectively reduce aggressive behavior in males that has been escalated by social instigation. Important sites of action for these drugs are the receptors in dorsal raphé nuclei (DRN) and the ventral–orbital prefrontal cortex (VO PFC). DRN and VO PFC areas are particularly relevant in the inhibitory control of escalated aggressive and impulsive behavior.