Structured intermittent treatment for HIV disease: Necessary concession or premature compromise?

摘要

The entree of potent antiretroviral ther- apy into the therapeutic armamentar- ium of HIV disease was an extraordinary moment in the history of the AIDS epi- demic. Mortality declined, morbidity di- minished, hospitalizations decreased, and the transition of HIV from a hospital- based to an outpatient disease com- menced (1). The guiding principles of antiretroviral therapy were grounded on landmark studies of HIV viral dynamics and our understanding of drug resistance (2, 3).