• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells
【24h】

Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells

机译：基因工程造血干细胞在体内产生的抗原特异性CD8 T细胞的抗肿瘤活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The body's immune defenses are a formidable weapon against cancer, and therefore therapies manipulating natural immune responses have been developed. However, tumors have evolved mechanisms to evade the body's defenses, compromising the efficacy of current interventions. Our study aimed to engineer stem cells genetically and, using a humanized mouse model, to create an immune system with potent and lasting antitumor properties. This approach led to the development of mature and effective antimelanoma (anti-skin cancer) T cells (white blood cells important to immune responses) that were able to target and eliminate tumors effectively. Although this study focused on a single human cancer, the scientific yield from these proposed studies could have a significant public health impact for other forms of cancer, infectious diseases, and even autoimmune disorders, including multiple sclerosis'and rheumatoid arthritis.
机译：人体的免疫防御是抵抗癌症的强大武器，因此已经开发出可操纵自然免疫反应的疗法。但是，肿瘤已经发展出逃避人体防御的机制，从而损害了当前干预措施的功效。我们的研究旨在通过基因工程改造干细胞，并使用人性化的小鼠模型来创建具有有效和持久抗肿瘤特性的免疫系统。这种方法导致能够有效靶向和消灭肿瘤的成熟有效的anlanlanoma（抗皮肤癌）T细胞（对免疫反应重要的白细胞）的发展。尽管本研究仅针对单一人类癌症，但这些拟议研究的科学成果可能对其他形式的癌症，传染病，甚至自身免疫性疾病（包括多发性硬化症和类风湿性关节炎）产生重大的公共卫生影响。

著录项

  • 来源
  • 作者

    Dimitrios N. Vatakis; Richard C. Koya; Christopher C. Nixon; Liu Wei; Sohn G. Kim; Patricia Avancena; Gregory Bristol; David Baltimore; Donald B. Kohn; Antoni Ribas; Caius G. Radu; Zoran Galic; Jerome A. Zack;

  • 作者单位

    Departments of Medicine, Division of Hematology-Oncology, David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of University of California, Los Angeles AIDS Institute, David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at University of California Los Angeles and David Geffen School of Medicine at the University of California, Los Angeles CA 90095;

    rnDepartments of University of California, Los Angeles AIDS Institute, David Geffen School of Medicine at the University of California, Los Angeles CA 90095;

    Departments of University of California, Los Angeles AIDS Institute, David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at University of California Los Angeles and David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of Microbiology Immunology and Molecular Genetics, David Geffen School of Medicine at the University of California, Los Angeles CA 90095;

    Departments of Molecular and Medical Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles CA 90095;

    Departments of Medicine, Division of Hematology-Oncology, David Geffen School of Medicine at the University of California, Los Angeles CA 90095;

    Departments of Medicine, Division of Hematology-Oncology, David Geffen School of Medicine at the University of California, Los Angeles CA 90095;

    Departments of Medicine, Division of Hematology-Oncology, David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of University of California, Los Angeles AIDS Institute, David Geffen School of Medicine at the University of California, Los Angeles CA 90095;

    Departments of Department of Biology, California Institute of Technology, Pasadena, CA 91125;

    Departments of University of California, Los Angeles AIDS Institute, David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of Microbiology Immunology and Molecular Genetics, David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of Department of Biology, California Institute of Technology, Pasadena, CA 91125;

    Departments of Medicine, Division of Hematology-Oncology, David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at University of California Los Angeles and David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of Surgery, Division of Surgical Oncology, David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at the University of California, Los Angeles CA 90095;

    Departments of Molecular and Medical Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles CA 90095;

    Departments of Medicine, Division of Hematology-Oncology, David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of University of California, Los Angeles AIDS Institute, David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at University of California Los Angeles and David Geffen School of Medicine at the University of California, Los Angeles CA 90095;

    Departments of Medicine, Division of Hematology-Oncology, David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of University of California, Los Angeles AIDS Institute, David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at University of California Los Angeles and David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of Microbiology Immunology and Molecular Genetics, David Geffen School of Medicine at the University of California, Los Angeles CA 90095,Departments of Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at the University of California, Los Angeles CA 90095;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号