Modulatory profiling identifies mechanisms of small molecule-induced cell death

摘要

Cell death is a central process in biology and disease. Too much cell death can lead to neurode-generative disease, diabetes, or heart failure; too little cell death can lead to cancer or autoimmune disease. Recent studies have shown that cells can die through a number of distinct but interconnected processes (1, 2). Understanding the relationship between different cell death pathways and disease states is impeded by an incomplete understanding of the full range of cell death processes that occur in cells, particularly in response to small molecules.