Hedgehog takes basolateral route to establish gradient

摘要

The Hedgehog signaling pathway is an important regulator of animal body plan development. In the Drosophila wing imaginal disc-a larval structure that forms the wing in adulthood-cells in the posterior of the disc release the Hedgehog protein (Hh) to form a gradient that specifies the an- tenor/postenor axis. Ainhoa Callejo et al. (pp. 12591-12598) tackled the long disputed question of whether the gradient forms along the apical or the basolateral plasma membrane of the disc epithelium in anterior cells.