Viral MHC class I inhibition evades CD8~+ T-cell effector responses in vivo but not CD8~+ T-cell priming

摘要

Viruses and their mammalian hosts have coevolved so that viruses encode molecules that affect the host immune response, and the host has strategies to counteract viral molecules. Studies of interactions of viruses with their hosts provide valuable clues for understanding better the basis for more effective control of viral infections. Moreover, studies of infections in an appropriate host have much to teach us about how the immune system functions. Here we studied how cowpox virus (CPXV) evades a major arm of the host immune response, the T cell, during active infections.