High-throughput genomic sequencing of cassava bacterial blight strains identifies conserved effectors to target for durable resistance

摘要

Sir Rowland Biffen (1874-1949), building upon Gregor Mendel's (1822-1884) work on'inheritance, demonstrated that resistance to yellow rust of wheat was controlled by a single gene, revolutionizing the field of plant breeding (1). Soon thereafter, work by Henry Harold Flor (1900-1991) and others led to the "gene-for-gene" model, in which induction of a resistance response was traceable to a single pathogen gene that matched a single resistance gene in the host(2). To this day, the introgression of resistance genes from wild species into agronomic crops is the preferred method of crop protection by geneticists, farmers, and consumers. Unfortunately, history has shown that most single genes for disease resistance are rapidly "defeated" in the field by pathogens that mutate to avoid recognition. We report here the results of next-generation sequence analysis of a significant bacterial plant pathogen that identifies ideal targets for developing resistance strategies for breeding sustainable and durable disease resistance.