Structural basis of histidine kinase autophosphorylation deduced by integrating genomics, molecular dynamics, and mutagenesis

摘要

The ongoing progress in sequencing and other high-throughput technologies combined with complementary bioinformatics tools have transformed the world of biology in the past decade and set the stage for the genomic revolution. However, the impact of such approaches on our understanding of cellular protein function at the molecular level have been limited. Many proteins are designed to transition between multiple conformations or interact with other biomolecules to exert their function.