K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis

摘要

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. In the past decade, the introduction of biological therapies that neutralize inflammatory cytokines such ; as TNF-α and IL-6 has been a major breakthrough, and has been successful in controlling disease activity and preventing or limiting joint destruction in the majority of patients. The primary disease-causing mechanisms have remained undetermined, and disease management therefore requires continuous therapy with these biological agents. Current clinical research is focused on identifying additional targets to block inflammation.