The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1 -binding small molecule

摘要

It is estimated that up to one-third of all proteins synthesized by eukaryotic cells are initially trafficked through the specialized environment of the endoplasmic reticulum (ER). In this subcellular compartment, conditions are optimized for protein folding and entry to the ER represents the first commitment step toward the secretory pathway.