HIV replication in CD4~+ T cells of HIV-infected individuals is regulated by a balance between the viral suppressive effects of endogenous β-chemokines and the viral inductive effects of other endogenous cytokines

摘要

This study demonstrates that the β-chemo- kines macrophage inflammatory proteins 1 and 1β(MIP-1 and MIP-1β) and, RANTES (regulated on activation, nor- mally T-cell expressed and secreted) inhibit human immuno- deficiency virus (HIV) replication in anti-CD3 or recall an- tigen-stimulated peripheral blood mononuclear cells (PB- MCs) of asymptomatic HIV-infected subjects. Significant levels of β-chemokines were produced by both CD4~+ and CD8~+ PBMC subsets from HIV-infected individuals.