INACTIVATION OF VIRAL GENOME REPLICATION IN THE MIDGUT OF INSECT VECTORS BY ACTIVATING ENDOGENOUS ANTI-VIRAL DEFENSE PATHWAYS

摘要

The present invention includes a novel paratransgenic system for the implementation of endogenous and RNAi-based expression strategies in which natural mosquito symbiotic bacteria configured to express endogenous genes or interfering RNA polynucleotides that are targeted to mosquito or viral genes resulting in the inhibition of viral infection, colonization, replication or transmission.