Selectively replicating viral vectors and process of its preparation, pharmaceutical formulation, method of killing a cell having defective pathway, transformed cell and promoter responsive to p53 and TGF-{beta} pathways

摘要

In the present invention, there is disclosed a selectively replicating viral vector comprising a pathway-responsive promoter operably linked to a repressor of viral replication wherein the vector being selectively replicated in neoplastic cells having defective pathway to which the promoter reacts.