Deregulation of PAX-5 by translocation of the Eμ enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma

摘要

Analyses of the human PAX-5 locus and of the 5' region of the mouse Pax-5 gene revealed that transcription from two distinct promoters results in splicing of two alter- native 5' exons to the common coding sequences of exons 2-10. Transcription from the upstream promoter initiates down- stream of a TATA box and occurs predominantly in B- lymphocytes, whereas the TATA-less downstream promoter is active in all Pax-5-expressing tissues.