Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p- dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage

摘要

While there was a significant 7.0-fold increase over 2 days in the excretion rate of oxo Gua into the growth medium of TCDD-treated Hepa1c1c7 cells compared to con- trol, no significant increase was detected in the steady-state level of oxo dG in the DNA presumably due to efficient DNA repair. Thus, the induction of CYP1A1 appears to lead to a leak of oxygen radicals and consequent oxidative DNA damage that could lead to mutation and cancer.