The peptide binding site of the substance P (NK-1) receptor localized by a photoreactive analogue of substance P: Presence of a disulfide bond

摘要

Substance P (SP) is a neuropeptide that mediates multiple physiological responses including trans- mission of painful stimuli and inflammation via an interac- tion with a receptor of known primary sequence. To identify the regions of the SP receptor, also termed the NK-1 receptor, involved in peptide recognition, we are using analogues of SP containing the photoreactive amino acid p-benzoyl-L- phenylalanine (Bpa).