Effect of estrogen upon cyclic ADP ribose metabolism: β-Estradiol stimulates ADP ribosyl cyclase in rat uterus

摘要

Cyclic ADP ribose (cADPR) has been shown to trigger Ca~2+ release from intracellular stores through ryanodine receptor/channel. In our previous study we ob- served that all-trans-retinoic acid stimulates cADPR synthesis by ADP ribose cyclase (ADPR cyclase) in cultured epithelial cells. We have now investigated whether cADPR may play a signaling role in action of β-estradiol (E_2), an archetypal steroid superfamily hormone, upon its major target organ, uterus, in vivo.