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Development status of the life marker chip instrument for ExoMars

机译:ExoMars生命标记芯片仪器的开发现状

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摘要

The Life Marker Chip (LMC) is one of the instruments being developed for possible flight on the 2018 ExoMars mission. The instrument uses solvents to extract organic compounds from samples of martian regolith and to transfer the extracts to dedicated detectors based around the use of antibodies. The scientific aims of the instrument are to detect organics in the form of biomarkers that might be associated with extinct life, extant life or abiotic sources of organics. The instrument relies on a novel surfactant-based solvent system and bespoke, commercial and research-developed antibodies against a number of distinct biomarkers or molecular types. The LMC comprises of a number of subsystems designed to accept up to four discrete samples of martian regolith or crushed rock, implement the solvent extraction, perform microfluidic-based multiplexed antibody-assays for biomarkers and other targets, optically detect the fluorescent output of the assays, control the internal instrument pressure and temperature, in addition to the associated instrument control electronics and software. The principle of operation, the design and the instrument development status as of December 2011 are reported here. The instrument principle can be extended to other configurations and missions as needed.
机译:生命标记芯片(LMC)是为在2018年ExoMars任务中可能飞行而开发的仪器之一。该仪器使用溶剂从火星长石样品中提取有机化合物,并将提取物转移到基于抗体使用的专用检测器中。该仪器的科学目的是检测生物标志物形式的有机物,这些生物标志物可能与生物的灭绝,现存生命或非生物来源有关。该仪器依赖于新型的基于表面活性剂的溶剂系统以及针对多种不同生物标记或分子类型的定制,商业化和研究开发的抗体。 LMC由多个子系统组成,这些子系统设计为最多接受四个离散的火星重碎石或碎石样品,实施溶剂提取,对生物标志物和其他目标物进行基于微流体的多重抗体测定,光学检测测定的荧光输出,除了控制相关的仪器控制电子设备和软件外,还控制仪器内部的压力和温度。此处报告了截至2011年12月的工作原理,设计和仪器开发状况。仪器原理可以根据需要扩展到其他配置和任务。

著录项

  • 来源
    《Planetary and space science》 |2012年第1期|129-137|共9页
  • 作者单位

    Space Research Centre, Michael Atiyah Building, Department of Physics and Astronomy, University of Leicester, Leicester LEI 7RH, United Kingdom;

    Cranfield Health, Vincent Building, Cranfleld University, Bedfordshire MK43 0AL, United Kingdom;

    Cranfield Health, Vincent Building, Cranfleld University, Bedfordshire MK43 0AL, United Kingdom;

    Cranfield Health, Vincent Building, Cranfleld University, Bedfordshire MK43 0AL, United Kingdom;

    Cranfield Health, Vincent Building, Cranfleld University, Bedfordshire MK43 0AL, United Kingdom;

    Cranfield Health, Vincent Building, Cranfleld University, Bedfordshire MK43 0AL, United Kingdom;

    Cranfield Health, Vincent Building, Cranfleld University, Bedfordshire MK43 0AL, United Kingdom;

    Cranfield Health, Vincent Building, Cranfleld University, Bedfordshire MK43 0AL, United Kingdom;

    Cranfield Health, Vincent Building, Cranfleld University, Bedfordshire MK43 0AL, United Kingdom;

    Cranfield Health, Vincent Building, Cranfleld University, Bedfordshire MK43 0AL, United Kingdom;

    Department of Earth Science and Engineering, South Kensington Campus, Imperial College London, London SW7 2AZ, United Kingdom;

    Department of Earth Science and Engineering, South Kensington Campus, Imperial College London, London SW7 2AZ, United Kingdom;

    Magna Parva Ltd., 2 Meridian South, Leicester LE19 1WY, United Kingdom;

    Magna Parva Ltd., 2 Meridian South, Leicester LE19 1WY, United Kingdom;

    Magna Parva Ltd., 2 Meridian South, Leicester LE19 1WY, United Kingdom;

    Space Research Centre, Michael Atiyah Building, Department of Physics and Astronomy, University of Leicester, Leicester LEI 7RH, United Kingdom;

    Space Research Centre, Michael Atiyah Building, Department of Physics and Astronomy, University of Leicester, Leicester LEI 7RH, United Kingdom;

    Space Research Centre, Michael Atiyah Building, Department of Physics and Astronomy, University of Leicester, Leicester LEI 7RH, United Kingdom;

    Space Research Centre, Michael Atiyah Building, Department of Physics and Astronomy, University of Leicester, Leicester LEI 7RH, United Kingdom;

    Space Research Centre, Michael Atiyah Building, Department of Physics and Astronomy, University of Leicester, Leicester LEI 7RH, United Kingdom;

    Space Research Centre, Michael Atiyah Building, Department of Physics and Astronomy, University of Leicester, Leicester LEI 7RH, United Kingdom;

    Dutch Space BV, Mendelweg 30, 2333 CS Leiden, The Netherlands;

    Lionix BV, Hallenweg 6, Building 89 (Langezijds A), 7522 NH Enschede, The Netherlands;

    Lionix BV, Hallenweg 6, Building 89 (Langezijds A), 7522 NH Enschede, The Netherlands;

    Kayser Italia S.r.l., Via di Popogna 501, 57128 Livomo, Italy;

    Kayser Italia S.r.l., Via di Popogna 501, 57128 Livomo, Italy;

    Kayser Italia S.r.l., Via di Popogna 501, 57128 Livomo, Italy;

    INAF Osservatorio Astrofisico di Arcetri, Lgo E. Fermi 5, 50125 Firenze, Italy;

    Department of Geological Sciences, Stockholm University, 106 91 Stockholm, Sweden;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    mars; exomars; extraterrestrial life; astrobiology; life marker chip;

    机译:火星;exomas;外星生命天体生物学生命标记芯片;

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