Investigation of the free volume in olanzapine by PALS

摘要

Two polymorphic forms of olanzapine were investigated as a function of temperature in a range from 100 to 420 K and as a function of hydrostatic pressure from 0 to 1300 MPa using positron annihilation lifetime spectroscopy. In the crystallo-rngraphic structure of both investigated forms exists component ascribed to positronium formation. The lifetime value of o-Ps changes nonmonotinicaly from 1.0 to 1.6 ns as a function of temperature.