Major Involvement of Low-Density Lipoprotein Receptor-Related Protein 1 in the Clearance of Plasma Free Amyloid β-Peptide by the Liver

Chihiro Tamaki; Sumio Ohtsuki; Takeshi Iwatsubo; Tadafumi Hashimoto; Kaoru Yamada; Chiori Yabuki; Tetsuya Terasaki

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Major Involvement of Low-Density Lipoprotein Receptor-Related Protein 1 in the Clearance of Plasma Free Amyloid β-Peptide by the Liver

机译：低密度脂蛋白受体相关蛋白1在肝脏清除血浆游离淀粉样β肽中的主要作用

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摘要

To identify the molecules responsible for amyloid β-peptide (1–40) (Aβ(1–40)) uptake by the liver, which play a major role in the systemic clearance of Aβ(1–40).

机译：识别负责肝脏摄取淀粉样蛋白β肽（1–40）（Aβ（1–40））的分子，这些分子在Aβ（1–40）的全身清除中起主要作用。

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来源
《Pharmaceutical Research》 |2006年第7期|1407-1416|共10页
作者
Chihiro Tamaki; Sumio Ohtsuki; Takeshi Iwatsubo; Tadafumi Hashimoto; Kaoru Yamada; Chiori Yabuki; Tetsuya Terasaki;
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作者单位

Department of Molecular Biopharmacy and Genetics Graduate School of Pharmaceutical Sciences Tohoku University Aoba Aramaki Aoba-ku Sendai 980-8579 Japan;

Department of Molecular Biopharmacy and Genetics Graduate School of Pharmaceutical Sciences Tohoku University Aoba Aramaki Aoba-ku Sendai 980-8579 Japan;

Department of Neuropathology and Neuroscience Graduate School of Pharmaceutical Sciences University of Tokyo 7-3-1 Hongo Bunkyoku Tokyo 113-0033 Japan;

Department of Neuropathology and Neuroscience Graduate School of Pharmaceutical Sciences University of Tokyo 7-3-1 Hongo Bunkyoku Tokyo 113-0033 Japan;

Department of Neuropathology and Neuroscience Graduate School of Pharmaceutical Sciences University of Tokyo 7-3-1 Hongo Bunkyoku Tokyo 113-0033 Japan;

Department of Neuropathology and Neuroscience Graduate School of Pharmaceutical Sciences University of Tokyo 7-3-1 Hongo Bunkyoku Tokyo 113-0033 Japan;

Department of Molecular Biopharmacy and Genetics Graduate School of Pharmaceutical Sciences Tohoku University Aoba Aramaki Aoba-ku Sendai 980-8579 Japan;

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正文语种 eng
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amyloid β-peptide; clearance; liver uptake index; low-density lipoprotein receptor-related protein 1; receptor-mediated endocytosis;

机译：β淀粉样蛋白;清除率;肝脏摄取指数;低密度脂蛋白受体相关蛋白1;受体介导的内吞作用;

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专利

1. Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver. [J] . Tamaki C, Ohtsuki S, Iwatsubo T, Pharmaceutical research . 2006,第7期

机译：低密度脂蛋白受体相关蛋白1主要参与肝脏清除血浆游离淀粉样β肽的活动。
2. Insulin facilitates the hepatic clearance of plasma amyloid beta-peptide (1 40) by intracellular translocation of low-density lipoprotein receptor-related protein 1 (LRP-1) to the plasma membrane in hepatocytes. [J] . Tamaki C, Ohtsuki S, Terasaki T Molecular pharmacology. . 2007,第4期

机译：胰岛素通过低密度脂蛋白受体相关蛋白1（LRP-1）向肝细胞质膜的细胞内转运，促进血浆淀粉样β肽（1 40）的肝清除。
3. Transthyretin promotes amyloid beta peptide clearance through the low-density lipoprotein receptor-related protein 1 in the liver [J] . Alemi Mobina, Gaiteiro Cristiana, Ribeiro Carlos Alexandre, Medicine. . 2016,第10期

机译：运甲状腺素蛋白通过肝脏中低密度脂蛋白受体相关蛋白1促进淀粉样β肽清除
4. Role of lysine residues in the interaction of blood coagulation factor VIII with its clearance receptor low-density lipoprotein receptor-related protein [C] . M. van den Biggelaar, J.H. Faber, M. Zuurveld, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：赖氨酸残基在血液凝固因子VIII与其间隙受体低密度脂蛋白受体相关蛋白的作用
5. The mechanism of the low-density lipoprotein receptor-related protein (LRP) in the production of amyloid-beta peptide. [D] . Chen, Eunice Chungyu. 2008

机译：低密度脂蛋白受体相关蛋白（LRP）在淀粉样β肽生产中的机制。
6. Low-density lipoprotein receptor-related protein-1 : a serial clearance homeostatic mechanism controlling Alzheimers amyloid β-peptide elimination from the brain [O] . Berislav V. Zlokovic, Rashid Deane, Abhay P. Sagare, -1

机译：低密度脂蛋白受体相关的蛋白-1：一种序列间隙性稳态机制控制来自脑的阿尔茨海默氏蛋白β-肽的消除
7. Lack of brain-to-blood efflux transport activity of low-density lipoprotein receptor-related protein-1 (LRP-1) for amyloid-β peptide(1-40) in mouse: involvement of an LRP-1-independent pathway [O] . Shingo Ito, Takashi Ueno, Sumio Ohtsuki, 2010

机译：小鼠中缺乏低密度脂蛋白受体相关蛋白-1（LRP-1）的低密度脂蛋白受体相关蛋白-1（LRP-1）的脑血流动迁移活性：LRP-1无关的途径的累积

Major Involvement of Low-Density Lipoprotein Receptor-Related Protein 1 in the Clearance of Plasma Free Amyloid β-Peptide by the Liver

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