Pharmacokinetics of the CYP 3A Substrate Simvastatin following Administration of Delayed Versus Immediate Release Oral Dosage Forms

Marija Tubic-Grozdanis; John M. Hilfinger; Gordon L. Amidon; Jae Seung Kim; Paul Kijek; Petra Staubach; Peter Langguth

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Pharmacokinetics of the CYP 3A Substrate Simvastatin following Administration of Delayed Versus Immediate Release Oral Dosage Forms

机译：CYP 3A底物辛伐他汀在延迟与立即释放口服剂型给药后的药代动力学

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摘要

The study was designed to evaluate the effect of delayed release (DR) on absorption and bioavailability of intestinally metabolized drugs after oral dosing, using the HMG-CoA reductase inhibitor simvastatin, a CYP3A substrate, as a model drug.

机译：该研究旨在使用HMG-CoA还原酶抑制剂辛伐他汀（一种CYP3A底物）作为模型药物，评估口服给药后延迟释放（DR）对肠道代谢药物吸收和生物利用度的影响。

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来源
《Pharmaceutical Research》 |2008年第7期|1591-1600|共10页
作者
Marija Tubic-Grozdanis; John M. Hilfinger; Gordon L. Amidon; Jae Seung Kim; Paul Kijek; Petra Staubach; Peter Langguth;
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作者单位

Department of Pharmaceutical Technology and Biopharmaceutics Johannes Gutenberg-University Staudinger Weg 5 55099 Mainz Germany;

TSRL Inc. 540 Avis Drive Suite A Ann Arbor Michigan 48108 USA;

College of Pharmacy The University of Michigan 428 Church Street Ann Arbor Michigan 48109-1065 USA;

TSRL Inc. 540 Avis Drive Suite A Ann Arbor Michigan 48108 USA;

TSRL Inc. 540 Avis Drive Suite A Ann Arbor Michigan 48108 USA;

Department of Dermatology University Hospital Mainz Clinical Research Center Langenbeckstr.1 55101 Mainz Germany;

Department of Pharmaceutical Technology and Biopharmaceutics Johannes Gutenberg-University Staudinger Weg 5 55099 Mainz Germany;

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原文格式 PDF
正文语种 eng
中图分类
关键词
colon delivery; CYP 3A; metabolism; modified release; simvastatin;

机译：结肠传递;CYP 3A;代谢;缓释;辛伐他汀;

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专利

1. Pharmacokinetics of the CYP 3A substrate simvastatin following administration of delayed versus immediate release oral dosage forms. [J] . Tubic-Grozdanis M, Hilfinger JM, Amidon GL, Pharmaceutical research . 2008,第7期

机译：CYP 3A底物辛伐他汀在延迟和立即释放口服剂型给药后的药代动力学。
2. Pharmacokinetics of the CYP 3A substrate simvastatin following administration of delayed versus immediate release oral dosage forms. [J] . Tubic-Grozdanis M, Hilfinger JM, Amidon GL, Pharmaceutical research . 2008,第7期

机译：CYP 3A底物辛伐他汀在延迟和立即释放口服剂型给药后的药代动力学。
3. Development of oral immediate release and Sustained release dosage form of Simvastatin and its Pharmacokinetic evaluation [J] . BasuvanBabu, Subramania Nainar Meyyanathan, ByranGowramma, International Journal of Analytical and Bioanalytical Chemistry . 2012,第4期

机译：辛伐他汀口服即释和缓释剂型的研制及其药代动力学评价
4. Physiologically based pharmacokinetic modeling of immediate and delayed release dosage forms [C] . M. Di Muria, G. Lamberti, G. Titomanlio Annual meeting exposition of the Controlled Release Society . 2009

机译：立即和延迟释放剂型的基于生理的药代动力学模型
5. Improvement of release criteria for immediate release solid oral dosage forms. [D] . Lunney, Phillip Douglas. 2012

机译：改善速释固体口服剂型的释放标准。
6. Azathioprine pharmacokinetics after intravenous oral delayed release oral and rectal foam administration. [O] . E C Van Os, B J Zins, W J Sandborn, 1996

机译：静脉口服延迟释放口服和直肠泡沫给药后硫唑嘌呤的药代动力学。
7. Analysis of the impact of controlled release formulation on oral drug absorption, gut wall metabolism and relative bioavailability of CYP3A substrates using a physiologically-based pharmacokinetic model [O] . Olivares-Morales, Andrés, Kamiyama, Yoshiteru, Darwich, Adam S, 2015

机译：使用基于生理学的药代动力学模型分析控释制剂对口服药物吸收，肠壁代谢和CYp3a底物相对生物利用度的影响
8. Guidance for Industry. Waiver of In Vivo Bioavailability and BioequivalenceStudies for Immediate-Release Solid Oral Dosage Forms Based on a Biopharmaceutics Classification System [R] . 2000

机译：工业指南。基于生物药剂学分类系统，立即释放固体口服剂型的体内生物利用度和生物等效性研究的放弃

Pharmacokinetics of the CYP 3A Substrate Simvastatin following Administration of Delayed Versus Immediate Release Oral Dosage Forms

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