Formulation and Pharmacokinetics of Self-Assembled Rifampicin Nanoparticle Systems for Pulmonary Delivery

Jean C. Sung; Danielle J. Padilla; Lucila Garcia-Contreras; Jarod L. VerBerkmoes; David Durbin; Charles A. Peloquin; Katharina J. Elbert; Anthony J. Hickey; David A. Edwards

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Formulation and Pharmacokinetics of Self-Assembled Rifampicin Nanoparticle Systems for Pulmonary Delivery

机译：自组装的利福平纳米颗粒肺给药系统的配方和药代动力学

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Purpose To formulate rifampicin, an anti-tuberculosis antibiotic, for aerosol delivery in a dry powder ‘porous nanoparticle-aggregate particle’ (PNAP) form suited for shelf stability, effective dispersibility and extended release with local lung and systemic drug delivery.

机译：目的配制抗结核性抗生素利福平，以干粉“多孔纳米颗粒-聚集颗粒”（PNAP）形式雾化气雾剂，适于保存稳定性，有效分散性和局部肺部和全身性药物释放的延长释放。

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《Pharmaceutical Research》 |2009年第8期|p.1847-1855|共9页
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Jean C. Sung; Danielle J. Padilla; Lucila Garcia-Contreras; Jarod L. VerBerkmoes; David Durbin; Charles A. Peloquin; Katharina J. Elbert; Anthony J. Hickey; David A. Edwards;
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1. Formulation and pharmacokinetics of self-assembled rifampicin nanoparticle systems for pulmonary delivery. [J] . Sung JC, Padilla DJ, Garcia Contreras L Pharmaceutical research . 2009,第8期

机译：自组装利福平纳米颗粒系统用于肺部给药的制剂和药代动力学。
2. Formulation and Evaluation of Novel Spray-dried Alginate Microspheres as Pulmonary Delivery Systems of Rifampicin in Rats [J] . Patil Jagadevappa S., Devi Kusum, Devi Kshama, Indian Journal of Pharmaceutical Education & Research . 2015,第4期

机译：新型喷雾干燥海藻酸盐微球作为利福平肺部给药系统的配方及评价
3. Biodegradable nano-micro carrier systems for sustained pulmonary drug delivery: (I) self-assembled nanoparticles encapsulated in respirable/swellable semi-IPN microspheres. [J] . El Sherbiny IM, Smyth HD International Journal of Pharmaceutics . 2010,第1a2期

机译：可生物降解的纳米微载体系统，用于持续的肺部药物输送：（I）封装在可呼吸/可溶胀的半IPN微球中的自组装纳米颗粒。
4. Toxicity and Pharmacokinetics of uPAR-targeted Human ATF-conjugated Iron Oxide Nanoparticles Following Systemic Delivery in rhesus Monkey [C] . Yushu Chen, Li Gong, Ning Gao, Annual NSTI nanotechnology conference and expo;TechConnect world innovation conference expo . 2014

机译：猕猴全身递送后靶向uPAR的人类ATF共轭氧化铁纳米粒子的毒性和药代动力学。
5. Nanoparticle agglomeration via ionic colloidal destabilization as a novel approach to dry powder formulations for pulmonary drug delivery. [D] . Plumley, Carl J. 2008

机译：通过离子胶体去稳定作用的纳米颗粒团聚是一种用于干粉制剂用于肺部药物输送的新方法。
6. Biodegradable nano-micro carrier systems for sustained pulmonary drug delivery: (I) Self-assembled nanoparticles encapsulated in respirable/swellable semi-IPN microspheres [O] . I. M. El-Sherbiny, H. D. C. Smyth -1

机译：用于持续肺药递送的可生物降解的纳米微型载体系统：（i）包封在可吸入/可溶胀的半IPN微球中的自组装纳米颗粒
7. Biodegradable nano-micro carrier systems for sustained pulmonary drug delivery: (I) Self-assembled nanoparticles encapsulated in respirable/swellable semi-IPN microspheres [O] . Ibrahim M. El-Sherbiny, Hugh D.C. Smyth 2010

机译：用于持续肺药递送的可生物降解的纳米微型载体系统：（i）包封在可吸入/可溶胀的半IPN微球中的自组装纳米颗粒

Formulation and Pharmacokinetics of Self-Assembled Rifampicin Nanoparticle Systems for Pulmonary Delivery

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