Dexamethasone 21-Sulfate Improves the Therapeutic Properties of Dexamethasone Against Experimental Rat Colitis by Specifically Delivering the Steroid to the Large Intestine

Inho Kim; Hyesik Kong; Younghyun Lee; Sungchae Hong; Jungoh Han; Sunhwa Jung; Yunjin Jung; Young Mi Kim

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Dexamethasone 21-Sulfate Improves the Therapeutic Properties of Dexamethasone Against Experimental Rat Colitis by Specifically Delivering the Steroid to the Large Intestine

机译：地塞米松21硫酸盐通过将类固醇专门递送至大肠来改善地塞米松对实验性大鼠结肠炎的治疗作用

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Purpose We investigated in vivo-colon targetability and therapeutic properties of DS against experimental rat colitis.

机译：目的我们研究了DS对实验性大鼠结肠炎的体内结肠靶向性和治疗特性。

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《Pharmaceutical Research》 |2009年第2期|p.415-421|共7页
作者
Inho Kim; Hyesik Kong; Younghyun Lee; Sungchae Hong; Jungoh Han; Sunhwa Jung; Yunjin Jung; Young Mi Kim;
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1. Dexamethasone 21-sulfate improves the therapeutic properties of dexamethasone against experimental rat colitis by specifically delivering the steroid to the large intestine. [J] . Kim I, Kong H, Lee Y, Pharmaceutical research . 2009,第2期

机译：硫酸地塞米松21硫酸盐通过将类固醇特异地递送至大肠来改善地塞米松对实验性大鼠结肠炎的治疗性能。
2. Synthesis and in vitro properties of dexamethasone 21-sulfate sodium as a colon-specific prodrug of dexamethasone. [J] . Kim IH, Kong HS, Choi BI, Drug development and industrial pharmacy . 2006,第3期

机译：地塞米松21-硫酸钠作为地塞米松结肠特异性前药的合成及其体外性质。
3. Erythrocytes-mediated delivery of dexamethasone 21-phosphate in steroid-dependent ulcerative colitis: a randomized, double-blind Sham-controlled study. [J] . Fabrizio Bossa, Vito Annese, Maria Rosa Valvano, Inflammatory bowel diseases . 2013,第9期

机译：在类固醇依赖性溃疡性结肠炎中，红细胞介导的地塞米松21-磷酸的递送：一项随机，双盲，Sham对照研究。
4. In Vivo Macrophage Activation via Locally Delivered Dexamethasone [C] . Geoff D. Keeler, Jeannine M. Durdik, Julie A. Stenken . 2015

机译：通过局部递送的地塞米松体内巨噬细胞激活
5. Enriching dendritic cells with granulocyte-macrophage colony stimulating factor and delivering dexamethasone-peptide immunoconjugates for attenuating T cell responses [D] . Sands, Roger Warren 2014

机译：用粒细胞-巨噬细胞集落刺激因子富集树突状细胞并递送地塞米松-肽免疫偶联物以减轻T细胞反应
6. Long-Term Therapeutic Effects of Mesenchymal Stem Cells Compared to Dexamethasone on Recurrent Experimental Autoimmune Uveitis of Rats [O] . Lingjun Zhang, Hui Zheng, Hui Shao, -1

机译：与地塞米松相比间充质干细胞对大鼠实验性自身免疫性葡萄膜炎的长期治疗作用
7. Long-term treatment with autologous red blood cells loaded with dexamethasone 21-phosphate in pediatric patients affected by steroid-dependent crohn disease and ulcerative colitis [O] . Papadatou, B, Rossi, Luigia, Bracci, F, 2009

机译：患有类固醇依赖性克罗恩病和溃疡性结肠炎的小儿患者长期接受自体红细胞和地塞米松21-磷酸负载
8. Regulation of Postnatal beta-Adrenergic Receptor/Adenylate Cyclase Development byPrenatal Agonist Stimulation and Steroids: Alterations in Rat Kidney and Lung after Exposure to Terbutaline or Dexamethasone [R] . Kudlacz, E. M., Navarro, H. A., Kavlock, R. J., 1990

机译：通过激动剂刺激和类固醇调节出生后β-肾上腺素能受体/腺苷酸环化酶的发生：接触特布他林或地塞米松后大鼠肾和肺的改变

Dexamethasone 21-Sulfate Improves the Therapeutic Properties of Dexamethasone Against Experimental Rat Colitis by Specifically Delivering the Steroid to the Large Intestine

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