Physicochemical Selectivity of the BBB Microenvironment Governing Passive Diffusion—Matching with a Porcine Brain Lipid Extract Artificial Membrane Permeability Model

Oksana Tsinman; Konstantin Tsinman; Na Sun; Alex Avdeef

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Physicochemical Selectivity of the BBB Microenvironment Governing Passive Diffusion—Matching with a Porcine Brain Lipid Extract Artificial Membrane Permeability Model

机译：BBB微环境控制被动扩散的理化选择性-匹配猪脑脂质提取物的人工膜通透性模型

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Purpose To mimic the physicochemical selectivity of the blood-brain barrier (BBB) and to predict its passive permeability using a PAMPA model based on porcine brain lipid extract (PBLE 10%w/v in alkane).

机译：目的使用基于猪脑脂质提取物（烷烃中PBLE 10％w / v）的PAMPA模型模拟血脑屏障（BBB）的物理化学选择性并预测其被动渗透性。

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《Pharmaceutical Research》 |2011年第2期|p.337-363|共27页
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Oksana Tsinman; Konstantin Tsinman; Na Sun; Alex Avdeef;
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专利

1. Physicochemical selectivity of the BBB microenvironment governing passive diffusion--matching with a porcine brain lipid extract artificial membrane permeability model. [J] . Tsinman O, Tsinman K, Sun N, Pharmaceutical research . 2011,第2期

机译：BBB微环境控制被动扩散的理化选择性-与猪脑脂质提取物人工膜通透性模型匹配
2. Selective association of phospholipids as a clue for the passive flip-flop diffusion through bilayer lipid membranes [J] . Movileanu L, Popescu D, Victor G, BioSystems . 1997,第3期

机译：磷脂的选择性缔合作为通过双层脂质膜的被动触发器扩散的线索
3. Prediction of the Passive Intestinal Absorption of Medicinal Plant Extract Constituents with the Parallel Artificial Membrane Permeability Assay (PAMPA) [J] . Petit Charlotte, Bujard Alban, Skalicka-Wozniak Krystyna, Planta medica: Natural products and medicinal plant research . 2016,第5期

机译：并行人工膜通透性测定（PAMPA）预测药用植物提取物成分的被动肠吸收
4. Permeability of an In Vitro Model of Blood Brain Barrier (BBB) [C] . Rashid Arnin, Temiz A. Artmann, Gerhard Artmann International Conference on Biomedical Engineering . 2008

机译：血脑屏障体外模型的渗透率（BBB）
5. PASSIVE ION TRANSPORT IN ARTIFICIAL LIPID BILAYER MEMBRANES. [D] . YU, ANDY WAN. 1984

机译：人工脂质双层膜中的被动离子传输。
6. Physicochemical Selectivity of the BBB Microenvironment Governing Passive Diffusion—Matching with a Porcine Brain Lipid Extract Artificial Membrane Permeability Model [O] . Oksana Tsinman, Konstantin Tsinman, Na Sun, -1

机译：用猪脑脂肪提取人工膜渗透性模型控制被动扩散匹配的BBB微环境的物理化学选择性
7. Physicochemical Selectivity of the BBB Microenvironment Governing Passive Diffusion—Matching with a Porcine Brain Lipid Extract Artificial Membrane Permeability Model [O] . Oksana Tsinman, Konstantin Tsinman, Na Sun, 2010

机译：用猪脑脂肪提取人工膜渗透性模型控制被动扩散匹配的BBB微环境的物理化学选择性

Physicochemical Selectivity of the BBB Microenvironment Governing Passive Diffusion—Matching with a Porcine Brain Lipid Extract Artificial Membrane Permeability Model

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