Pharmacokinetics, Antitumor and Cardioprotective Effects of Liposome-Encapsulated Phenylaminoethyl Selenide in Human Prostate Cancer Rodent Models

Jeong Yeon Kang; Mathew Eggert; Shravanthi Mouli; Ibrahim Aljuffali; Xiaoyu Fu; Ben Nie; Amy Sheil; Kendall Waddey; Charlie D. Oldham; Sheldon W. May; Rajesh Amin; Robert D. Arnold

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Pharmacokinetics, Antitumor and Cardioprotective Effects of Liposome-Encapsulated Phenylaminoethyl Selenide in Human Prostate Cancer Rodent Models

机译：脂质体包裹的苯氨基乙基硒化物在人前列腺癌啮齿动物模型中的药代动力学，抗肿瘤和心脏保护作用

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Purpose Cardiotoxicity associated with the use of doxorubicin (DOX), and other chemotherapeutics, limits their clinical potential. This study determined the pharmacokinetics and antitumor and cardioprotective activity of free and liposome encapsulated phenyl-2-aminoethyl-selenide (PAESe).

机译：目的与阿霉素（DOX）和其他化学疗法相关的心脏毒性限制了其临床潜力。这项研究确定了游离和脂质体包裹的苯基-2-氨基乙基硒化物（PAESe）的药代动力学，抗肿瘤和心脏保护活性。

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《Pharmaceutical Research》 |2015年第3期|852-862|共11页
作者
Jeong Yeon Kang; Mathew Eggert; Shravanthi Mouli; Ibrahim Aljuffali; Xiaoyu Fu; Ben Nie; Amy Sheil; Kendall Waddey; Charlie D. Oldham; Sheldon W. May; Rajesh Amin; Robert D. Arnold;
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Department of Pharmaceutical and Biomedical Sciences College of Pharmacy University of Georgia">(1);

Department of Drug Discovery Development Harrison School of Pharmacy Auburn University">(2);

Department of Drug Discovery Development Harrison School of Pharmacy Auburn University">(2);

Department of Pharmaceutical and Biomedical Sciences College of Pharmacy University of Georgia">(1);

Nanomedicine Research Unit Department of Pharmaceutics College of Pharmacy King Saud University">(4);

Department of Drug Discovery Development Harrison School of Pharmacy Auburn University">(2);

Department of Drug Discovery Development Harrison School of Pharmacy Auburn University">(2);

Department of Drug Discovery Development Harrison School of Pharmacy Auburn University">(2);

Department of Drug Discovery Development Harrison School of Pharmacy Auburn University">(2);

School of Chemistry Biochemistry Georgia Institute of Technology">(3);

School of Chemistry Biochemistry Georgia Institute of Technology">(3);

Department of Drug Discovery Development Harrison School of Pharmacy Auburn University">(2);

Department of Drug Discovery Development Harrison School of Pharmacy Auburn University">(2);

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1. Pharmacokinetics, Antitumor and Cardioprotective Effects of Liposome-Encapsulated Phenylaminoethyl Selenide in Human Prostate Cancer Rodent Models [J] . Kang Jeong Yeon, Eggert Mathew, Mouli Shravanthi, Pharmaceutical research . 2015,第3期

机译：脂质体包裹的苯氨基乙基硒化物在人前列腺癌啮齿动物模型中的药代动力学，抗肿瘤和心脏保护作用
2. The antioxidant phenylaminoethyl selenide reduces doxorubicin-induced cardiotoxicity in a xenograft model of human prostate cancer [J] . Kang J.Y., Costyn L.J., Nagy T., Archives of Biochemistry and Biophysics . 2011,第1a2期

机译：抗氧化剂苯氨基乙基硒化物降低人前列腺癌异种移植模型中阿霉素诱导的心脏毒性
3. Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: Synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model [J] . Handratta VD, Vasaitis TS, Njar VCO, Journal of Medicinal Chemistry . 2005,第8期

机译：新型C-17-杂芳基甾体CYP17抑制剂/抗雄激素药物：LAPC4人前列腺癌异种移植模型中的合成，体外生物学活性，药代动力学和抗肿瘤活性
4. PENDANT POLY(ETHYLENE GLYCOL) DRUG CARRIER: ANTITUMOR EFFICACY, BODY DISTRIBUTION, PHARMACOKINETICS, EXCRETION IN RODENT AND SUBCELLULAR TRAFFICKING [C] . R. Prakash, V. Omelyanenko, C. Clemens, Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

机译：侧链聚乙二醇药物载体：抗肿瘤功效，身体分布，药代动力学，啮齿动物和皮下细胞排泄
5. Studies on human prostate-specific antigen as a tumor antigen for the immunotherapy of prostate cancer in a mouse model. [D] . Willis, Richard Allen. 2002

机译：人类前列腺特异性抗原作为一种肿瘤抗原的免疫模型在小鼠模型中的研究。
6. Pharmacokinetics Antitumor and Cardioprotective Effects of Liposome-Encapsulated Phenylaminoethyl Selenide in Human Prostate Cancer Rodent Models [O] . Jeong Yeon Kang, Mathew Eggert, Shravanthi Mouli, -1

机译：脂质体包裹的苯氨基乙基硒化物在人前列腺癌啮齿动物模型中的药代动力学抗肿瘤和心脏保护作用
7. The Cardioprotective Mechanism of Phenylaminoethyl Selenides (PAESe) Against Doxorubicin-Induced Cardiotoxicity Involves Frataxin [O] . Xiaoyu Fu, Mathew Eggert, Sieun Yoo, 2021

机译：苯基氨基甲基硒（PAESE）对多柔比蛋白诱导的心脏毒性的心脏保护机制涉及弗拉其辛

Pharmacokinetics, Antitumor and Cardioprotective Effects of Liposome-Encapsulated Phenylaminoethyl Selenide in Human Prostate Cancer Rodent Models

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