Heterobifunctional Multivaient Inhibitor-Adaptor Mediates Specific Aggregation between Shiga Toxin and a Pentraxin

Dmitry Solomon; Pavel I.Kitov; Eugenia Paszkiewicz; Gordon A.Grant; Joanna M.Sadowska; David R.Bundle

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Heterobifunctional Multivaient Inhibitor-Adaptor Mediates Specific Aggregation between Shiga Toxin and a Pentraxin

机译：异双功能多效抑制剂-介导介导滋贺毒素和五味子毒素之间的特定聚集。

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The first example of a multivaient heterofunctional inhibitor-adaptor,called "BAIT",is described.This multivaient inhibitor-adaptor is able to capture a "target" receptor (Shiga toxin) through its recognition of one ligand of a heterobivalent headgroup while the other ligand binds to an endogenous "trap" protein (serum amyloid P component,SAP).BAIT showed markedly enhanced inhibition of toxin activity.An efficient synthesis of this multivaient cluster containing heterobifunctional Iigands was accomplished by chemical and chemoenzymatic approaches.

机译：描述了称为“ BAIT”的多价异功能抑制剂-适配子的第一个例子。这种多价异型抑制剂-适配子能够通过识别异二价首基的一个配体而捕获“靶”受体（志贺毒素）。配体与内源性“陷阱”蛋白（血清淀粉样蛋白P组分，SAP）结合。BAIT显着增强了对毒素活性的抑制。通过化学和化学酶方法有效合成了含有异双功能配体的多价簇。

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来源
《Organic letters》 |2005年第20期|p.4369-4372|共4页
作者
Dmitry Solomon; Pavel I.Kitov; Eugenia Paszkiewicz; Gordon A.Grant; Joanna M.Sadowska; David R.Bundle;
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Alberta Ingenuity Centre for Carbohydrate Science,Department of Chemistry,University of Alberta,Edmonton AB,T6G 2G2 Canada;

Alberta Ingenuity Centre for Carbohydrate Science,Department of Chemistry,University of Alberta,Edmonton AB,T6G 2G2 Canada;

Alberta Ingenuity Centre for Carbohydrate Science,Department of Chemistry,University of Alberta,Edmonton AB,T6G 2G2 Canada;

Alberta Ingenuity Centre for Carbohydrate Science,Department of Chemistry,University of Alberta,Edmonton AB,T6G 2G2 Canada;

Alberta Ingenuity Centre for Carbohydrate Science,Department of Chemistry,University of Alberta,Edmonton AB,T6G 2G2 Canada;

Alberta Ingenuity Centre for Carbohydrate Science,Department of Chemistry,University of Alberta,Edmonton AB,T6G 2G2 Canada;

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正文语种 eng
中图分类有机化学;
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入库时间 2022-08-18 00:02:07

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1. Heterobifunctional Multivaient Inhibitor-Adaptor Mediates Specific Aggregation between Shiga Toxin and a Pentraxin [J] . Dmitry Solomon, Pavel I.Kitov, Eugenia Paszkiewicz, Organic letters . 2005,第20期

机译：异双功能多效抑制剂-介导介导志贺毒素和五价毒素之间的特定聚集。
2. The synthesis of a multivalent heterobifunctional ligand for specific interaction with Shiga toxin 2 produced by E. coli O157:H7 [J] . Jacobson J.M., Kitov P.I., Bundle D.R. Carbohydrate research . 2013,第Null期

机译：用于与大肠杆菌O157：H7产生的志贺毒素2特异性相互作用的多价异双功能配体的合成
3. Impact of the Nature and Size of the Polymeric Backbone on the Ability of Heterobifunctional Ligands to Mediate Shiga Toxin and Serum Amyloid P Component Ternary Complex Formation [J] . David R. Bundle, Eugenia Paszkiewicz, George L. Mulvey, Toxins . 2011,第9期

机译：聚合物骨架的性质和大小对异双功能配体介导志贺毒素和血清淀粉样蛋白P组分三元复合物形成能力的影响。
4. Recent Developments in Rapid, Immunoassay-Based Methods for Shiga Toxin-Producing E. coli and Shiga Toxin - (PPT) [C] . Andrew Gehring Annual Rapid Detection for Food Safety Conference . 2016

机译：基于快速的免疫测定法的最新发展，用于滋阴生产大肠杆菌和滋阴毒素 - （PPT）
5. The Design, Synthesis and Evaluation of Multivalent Heterobifunctional Ligands Specific for Shiga Toxin 1 and Shiga Toxin 2 [D] . Jacobson, Jared Matthew. 2014

机译：滋阴1和滋阴毒素2的多价异双官能配体的设计，合成及评价
6. Impact of the Nature and Size of the Polymeric Backbone on the Ability of Heterobifunctional Ligands to Mediate Shiga Toxin and Serum Amyloid P Component Ternary Complex Formation [O] . Pavel I. Kitov, Eugenia Paszkiewicz, Joanna M. Sadowska, 2011

机译：聚合物骨架的性质和大小对异双功能配体介导志贺毒素和血清淀粉样P组分三元复合物形成能力的影响。
7. Impact of the Nature and Size of the Polymeric Backbone on the Ability of Heterobifunctional Ligands to Mediate Shiga Toxin and Serum Amyloid P Component Ternary Complex Formation [O] . Glen D. Armstrong, George L. Mulvey, Thomas P. Griener, 2011

机译：聚合物骨架的性质和大小对异双功能配体介导志贺毒素和血清淀粉样P组分三元复合物形成能力的影响。

Heterobifunctional Multivaient Inhibitor-Adaptor Mediates Specific Aggregation between Shiga Toxin and a Pentraxin

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