Total Synthesis of Ageladine A,an Angiogenesis Inhibitor from the Marine Sponge Agelas nakamurai

摘要

A 12-step total synthesis of the tricyclic heteroaromatic marine metabolite ageladine A has been achieved using a 6pi-azaelectrocyclization and a Suzuki-Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloropyridine as key steps.