Reactivity of N-(ω-haloalkyl)-β-lactams with regard to lithium aluminium hydride: novel synthesis of 1-(1-aryl-3-hydroxypropyl)aziridinesand 3-aryl-3-(N-propylamino)propan-1-ols

摘要

In summary, the reactivity of 1-(2-chloroethyl)- and 1-(3-bromopropyl)azetidin-2-ones with regard to lithium aluminium hydride has been evaluated for the first time. 4-Aryl-1-(2-chloroethyl)azetidin-2-ones were transformed into novel 1-(1-aryl-3-hydroxypr