6-Azauracil or 8-aza-7-deazaadenine nucleosides and oligonucleotides: the effect of 2'-fluoro substituents and nucleobase nitrogens on conformation and base pairing

摘要

Oligonucleotides containing 6-azapyrimidine- or 8-aza-7-deaza-purine 2'-deoxy-2'-fluoroarabinonucleosides 1c, 2c were synthesized using the phosphoramidite building blocks 3b and 4 by employing solid-phase synthesis. The nucleosides 1c, 2c as well as the