Highly efficient synthesis of medium-sized lactones via oxidative lactonization: concise total synthesis of isolaurepan

摘要

A catalytic amount of TEMPO in the presence of PhI(OAc)_2 effected oxidative lactonization of 1,6- and 1,7-diols, directly affording seven- and eight-membered lactones, respectively, in good yields.rnLactone is a common structural motif widely found in biologically active natural products and Pharmaceuticals. In addition, a number of synthetic methods for functionalization of lactones are currently available, making them especially useful synthetic intermediates for the preparation of cyclic ethers. Thus, the development of practical synthetic methods for lactones continues to be an important and fundamental research in organic synthesis.