Pd(0)-catalyzed cross-coupling of allyl halides with α-diazocarbonyl compounds or N-mesylhydra zones: synthesis of 1,3-diene compounds

摘要

With palladium catalysis, allyl bromides or chlorides react with a-diazocarbonyl compounds or N-mesyl-hydrazones to afford 1,3-diene derivatives. The reaction represents a novel and efficient method for the synthesis of 1,3-butadiene derivatives. Mechanistically, the reaction is proposed to follow a pathway involving the formation of a π-allylic palladium carbene complex and subsequent migratory insertion.