Process for the preparation of organic compounds by cross-coupling reaction catalyzed by a transition metal compound aryl-x, heteroaryl-x, cycloalkenyl-x, or alkenyl x, with an alkyl halide, alkenyl, cycloalkyl or cycloalkenyl.

摘要

Process for the preparation of organic compounds of general formula (I) wherein RR '(I) R represents an alkenyl aromatic moiety, heteroaromatic, cycloalkenyl or optionally substituted, and R' represents an alkyl residue, alkenyl, cycloalkyl or cycloalkenyl given case substituted by reaction of a corresponding compound of general formula (II) wherein RX (II) X is chlorine, bromine, iodine, diazonium, mesylate (methanesulfonate), tosylate (p- toluenesulfonate), or triflate (trifluoromethanesulfonate) and R has the meaning specified in formula (I), with a corresponding compound of general formula (III) wherein R'-Y (III) Y is chlorine, bromine or iodine, and R 'has the meaning specified in formula (I), wherein the reaction in the presence a) of stoichiometric amounts of elemental magnesium, based on the compound of general formula (II), and b) catalytic amounts of a compos is performed or transition metal, based on the compound of general (II) formula, the compound of the transition metal iron compound from the group of iron (II) chloride, iron chloride (III) acetylacetonate, iron (II) acetylacetonate, iron (III) acetate, iron (II) acetate, iron (III) chloride, iron (II) chloride, iron (III) complex of carbonyl iron or cobalt (II) chloride or cobalt bromide (II) and optionally in the presence c) of an additive containing nitrogen, oxygen and / or phosphorus in catalytic or stoichiometric amount based on the compound of general formula (II), and the reaction is performed as a procedure of a single stage in which the organomagnesium compound formed in situ as intermediate (Grignard reagent) is not isolated.