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High-sensitivity laser confocal tomography based on frequency-shifted feedback technique

机译:基于频移反馈技术的高灵敏度激光共焦断层扫描

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摘要

Laser confocal tomography faces severe challenges in weak signal detection such as biological tissue imaging and low-reflection interfaces measurement. An ultra-high sensitive optical confocal tomography based on laser frequency-shifted feedback imaging technology is presented, whose theoretical magnification can reach 10(6) notably without using high-gain detectors. In addition, this achievement possesses the same tomographic resolution as conventional laser confocal tomography without the need for spatial filtering devices. In this work, supported by theories and experiments, the lateral and vertical resolution, optical sensitivity, and system repeatability of LFCT and traditional LCT are investigated and analyzed quantificationally. Finally, comparison on the results of measuring the microfluidic device and biological tissue sections is conducted.
机译:激光共焦断层扫描面临弱信号检测中的严重挑战,例如生物组织成像和低反射界面测量。提出了一种基于激光频移反馈成像技术的超高敏感光学剖析性断层扫描,其理论放大率可以特别达到10(6)(6)个,而无需使用高增益探测器。此外,这种成就具有与传统激光共焦断层摄影相同的断层分辨率,而无需空间滤波装置。在这项工作中,通过理论和实验支持,对LFCT和传统LCT的横向和垂直分辨率,光学灵敏度和系统可重复性进行调查并定量地进行调查。最后,对测量微流体装置和生物组织切片的结果进行比较。

著录项

  • 来源
    《Optics and Lasers in Engineering 》 |2020年第6期| 106059.1-106059.10| 共10页
  • 作者单位

    Tsinghua Univ State Key Lab Precis Measurement Technol & Instru Beijing 100084 Peoples R China|Army Engn Univ PLA Dept Elect & Opt Engn Shijiazhuang 050051 Hebei Peoples R China;

    Tsinghua Univ State Key Lab Precis Measurement Technol & Instru Beijing 100084 Peoples R China|Army Engn Univ PLA Dept Elect & Opt Engn Shijiazhuang 050051 Hebei Peoples R China;

    Army Engn Univ PLA Dept Elect & Opt Engn Shijiazhuang 050051 Hebei Peoples R China;

    Beijing Forestry Univ Coll Sci Beijing 100083 Peoples R China;

    Tsinghua Univ State Key Lab Precis Measurement Technol & Instru Beijing 100084 Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Laser confocal tomography; Optical measurement; High sensitivity; Frequency-shifted feedback; Biological specimens imaging;

    机译:激光共焦断层扫描;光学测量;高灵敏度;频移反馈;生物标本成像;

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