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首页> 外文期刊>Nuclear Instruments & Methods in Physics Research >Study on bone resorption behavior of osteoclast under drug effect using ~(41)Ca tracing
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Study on bone resorption behavior of osteoclast under drug effect using ~(41)Ca tracing

机译：〜（41）Ca示踪研究破骨细胞在药物作用下的骨吸收行为

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摘要

The mechanisms governing calcium fluxes during bone remodeling processes in Osteoporosis (OP) patients are poorly known. Understanding the changes of Osteoclasts (OC) during this dynamic transition is important to prevent and cure OP. The exploration of long-lived ~(41)Ca (T_(1/2) = 1.04 × 10~5 years) tracer combined with AMS measurements leads to the possibility of monitoring the bone resorption behavior of OC in OP patients. In this work, the behavior of OC with the administration of Strontium Ranelate (SR), a drug for OP, was studied by using ~(41)Ca labeled hydroxyapatite (HAP) to simulate the bone. AMS on the HI-13 tandem accelerator at CIAE was used to determine trace amounts of ~(41)Ca. The results show that the technique of ~(41)Ca tracing with AMS can be used to quantitatively monitor the behavior of OC in bone resorption under the effects of drugs. Experimental details and preliminary results will be presented.
机译：骨质疏松症（OP）患者在骨重塑过程中控制钙通量的机制知之甚少。了解在此动态过渡过程中破骨细胞（OC）的变化对于预防和治愈OP很重要。探索长寿命〜（41）Ca（T_（1/2）= 1.04×10〜5年）示踪剂并结合AMS测量可监测OP患者OC的骨吸收行为。在这项工作中，通过使用〜（41）Ca标记的羟基磷灰石（HAP）模拟骨骼，研究了服用雷诺酸锶（SR）（一种OP药物）时OC的行为。使用CIAE HI-13串联加速器上的AMS来测定痕量〜（41）Ca。结果表明，AMS〜（41）Ca示踪技术可用于定量监测药物作用下OC在骨吸收中的行为。将介绍实验细节和初步结果。

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    Dong Kejun; Lu Liyan; He Ming; Ouyang Yinggen; Xue Yan; Li Chaoli; Wu Shaoyong; Wang Xianggao; Shen Hongtao; Gao Jianjun; Wang Wei; Chen Dafu; Xing Yonggang; Yuan Jian; Jiang Shan;

  • 作者单位

    China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413, China;

    China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413, China,CNNC Third Qinshan Nuclear Power Co. Ltd., Haiyan 314300, China;

    China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413, China;

    China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413, China;

    China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413, China;

    China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413, China;

    China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413, China;

    College of Physics Science and Technology, Guangxi University, Nanning 530004, China;

    College of Physics and Technology, Guangxi Normal University, Guilin 541004, China;

    Institute of Radiation Medicine, Fudan University, Shanghai 200032, China;

    China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413, China,China National Nuclear Corporation, Beijing 100822, China;

    Beijing Research Institute of Traumatology and Orthopaedics, Beijing 100035, China;

    Beijing Research Institute of Traumatology and Orthopaedics, Beijing 100035, China;

    China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413, China;

    China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413, China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    ~(41)Ca; accelerator mass spectrometry; biological tracing;

    机译：〜（41）钙;加速器质谱;生物示踪;

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